Kiramat Shah
University of Swat, Pakistan
Title: Synthesis and Characterization Of Supramolecules and Its Applications As A Chemosensor For Drugs
Biography
Biography: Kiramat Shah
Abstract
The monitoring of pharmaceutical drugs in the environment is of great importance word wide. For
example, in Karachi Pakistan due to contaminated water six children were died and about 200 were fill ill in 2005. A large number of pharmaceutical drugs in highly alarming amount were found in different components of drinking water (surface water, drainage, and effluent) of Karachi in the microgram-per-liter range during bioassay directed chemical analysis. The photophysical evaluation of supramolecular organic molecules as optical probes for detection of water toxins has been recognized to be very selective, sensitive, and economical as compared to the previously used methodologies.
Synthesis, characterization and molecular recognition properties of fluorene based supramolecular cleft is
reported. The cleft molecule was prepared in a single-step with good yield (85% yield), by linking Fluorene
with 1-ethyl piperazine. The cleft molecule was carefully characterized using various spectroscopic techniques such as NMR and mass spectrometry. The supramolecular interaction of cleft with amoxicillin, 6APA, aspirin, captopril, cefotaxime, ceftriaxone, cefuroxime, diclofenac, penicillin, and cephradine was evaluated by fluorescent spectroscopy. The molecular recognition studies showed that amoxicillin selectively binds with cleft in the presence of other drugs. The analytical method developed for the supramolecular interaction of molecular cleft and amoxicillin was validated at varying pH, concentration and temperature during recognition process. Job's plots indicated that the stochiometry of the interactions between the cleft and the amoxicillin was 1:1.