Mohamed O Amin
Kuwait University, Kuwait
Title: Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detection
Submitted Date: 22 August 2017
Biography
Mohamed O Amin completed his Graduation at Kuwait University and currently pursuing MSc in Medicinal Chemistry.
Abstract
This work describes a novel and versatile solid-state sensor for analytes detection using Ru(bpy)3rn2+-Ce(IV). Herein, we reportrnthe synthesis, characterisation, optimisation and application of a new type of hybrid nanoparticles (NPs). MesoporousrnTiO2-Ru(bpy)3rn2+ NPs were prepared using a modified sol-gel method by incorporating Ru(bpy)3rn2+ into the initial reactionrnmixture at various concentrations. The resultant bright orange precipitate was characterised via: TEM, N2 sorpometry, ICPOES,rnRaman and UV-Vis spectroscopy techniques. The concentration of Ru(bpy)3rn2+ complex in the NPs was quantified and itsrnchemiluminescence (CL) response was compared to the same concentration in the liquid phase using oxalate as model analyte.rnThe results showed that this type of hybrid material exhibited higher CL signal compared to the liquid phase due to enlargedrnsurface area of the hybrid NPs (~149.6 m²/g). The amount of TiO2-Ru(bpy)3rn2+. NPs and the effect of the oxidant flow rate werernalso investigated to optimize the CL signal. The optimized system was further used to detect oxalate and two pharmaceuticalrndrugs; imipramine and promazine. The linearity of both drugs was in the range of 1-100 pM with limits of detection (LoD) ofrn0.1 and 0.5 pM, respectively. This approach is considered simple, low cost, facile and can be applied to a wide range of analytes.
Elena A Vasileva
Natalia P Mishchenko and Sergey A Fedoreyev
Title: Main products of echinochrome A oxidative degradation
Submitted Date: 15 August 2017
Biography
Elena A Vasileva is a Junior Researcher in the Laboratory of Chemistry of Natural Quinonoid Compounds at G. B. Elyakov Pacific Institute of Bioorganic Chemistry,rnVladivostok, Russia. She has an experience in identification, isolation and structure elucidation of natural quinonoid compounds from plants, their cell cultures andrnsea urchins.
Abstract
In the last decade appeared a large number of publications on the therapeutic effectiveness of echinochrome A and drugrnpreparations based on it, and that arouse the interest in the whole world to search and investigate biologically active quinonoidrnpigments of sea urchins. Therefore, the study of the chemical properties of echinochrome A, in particular the stability of itsrnsolutions, is an urgent task for modern pharmaceuticals. To investigate stability of echinochrome A in aqueous solutions, 200rnmg of it was diluted 50-fold with distilled water saturated with atmospheric oxygen (pH 7.2), and was vigorously stirred atrnroom temperature for 48 hours. Echinochrome A was removed from the reaction mixture by extraction with chloroform, itsrnoxidation products were extracted with ethyl acetate and chromatographed on a Toyopearl HW-40 gel in a solvent systemrn20-50% EtOH containing 0.3% HCOOH. As a result, 7-ethyl-2,2,3,3,5,6,8-heptahydroxy-2,3-dihydro-1,4-naphthoquinone,rn2-(carboxycarbonyl)-4-ethyl-3,5,6-trihydroxybenzoic acid, echinolactone A (7-ethyl-5,6-dihydroxy-2,3-dioxo-2,3-rndihydrobenzofuran-4-carboxylic acid), 4-ethyl-3,5,6-trihydroxyphthalic acid and 4-ethyl-2-formyl-3,5,6-trihydroxybenzoicrnacid were isolated. The structures of compounds 2, 3, 5, 6 were established using high-resolution mass spectrometry (HR-ESIMS)rnand NMR, and of compound 4–using X-ray crystallography.