5^th Global Chemistry Congress September 04-06, 2017 London, UK

Satya P Dubey is a Research Associate at Cranfield University, UK. He has his expertise in several aspects of material sciences such as polymer,bio-polymer, nano-materials, composites, sustainable material, metal-polymer interfaces etc. His diligent, open and contextual evaluation model based on environmental friendly polymer synthesis creates new pathways for improving polymer industry. He developed this model after years of experience in research, evaluation,teaching and administration both in basic material chemistry research as well as in developing the mathematical model in several research institutions worldwide. The current development made by him considered as a step forward for the production of biodegradable and bio-compostable polymer through more safer and greener method.

The disposal of large amount of polymer waste is one of the major challenges of this century. Use of bio-degradable polymers obtained from sustainable sources presents a solution to this problem. Poly lactic acid (PLA), a bio-degradable polymer,can be synthesized from sustainable sources as corn, starch,sugarcane and chips.Ring opening polymerization (ROP) of lactide monomer using metal/bimetallic catalyst (Sn, Zn or Al) is the preferred method for synthesis of PLA. However, the PLA synthesized using such catalysts may contain trace elements of the catalyst. These catalyst traces are known carcinogens and as such should be (ideally) eliminated from the process. Continuous reactive extrusion of lactide monomer (using the suitable reaction input has the potential to increase the throughput, and this route has been explored in the literature. In this work, reactive extrusion experiments using stannous octoate Sn(Oct)2 and tri-phenyl phosphine (PPh)3, were considered to perform ROP of lactide monomer using the microwave as an alternative energy (AE) source for activating and/or boosting the polymerization (Figure 1). Implementation of a microwave generator in a section of the extruder is one of the novelties of this research. A simulation model of ROP of PLA was formulated to estimate the impact of reaction kinetic and AE source on the polymerization process. Ludovic® software was used for the simulation of continuous reactive extrusion of the process. Experimental and simulated results were compared for the validation of the methodology. This work also highlights the advantages and drawbacks of most conventional metal catalysts, the effect of alternative energies on reaction mechanism, and safe and efficient production of PLA.

 

Figure 1 Polymerization overview

 

Recent Publications:

1. Satya P Dubey¹, Hrushikesh A Abhyankar, Veronica Marchante, James L Brighton, Kim Blackburn, Clive Temple, Björn Bergmann, Giang Trinh, Chantal David, “Modelling and Validation of Synthesis of Poly Lactic Acid using Alternative Energy Source through Continuous Reactive Extrusion Process” Polymers (Vol:8, 164; doi:10.3390/polym8040164 2016
2. Satya P Dubey¹, Hrushikesh A Abhyankar, Veronica Marchante, James L Brighton, Björn Bergmann, Giang Trinh, Chantal David, “Microwave Energy assisted Synthesis of Poly Lactic Acid through Continuous Reactive Extruder: Reaction kinetics modelling approach” (RSC Advances, 2017, 7, 18529 – 18538. DOI: 10.1039/c6ra26514f.)
3. Satya P Dubey¹, Hrushikesh A Abhyankar, Veronica Marchante, James L Brighton, Kim Blackburn, “Review on catalytic progress on poly lactic acid formation through ring opening polymerization” (International Research Journal of Pure and Applied Chemistry)”. 2016 – Vol: 12, issue 3, IRJPAC/26179
4. Satya P Dubey¹, Hrushikesh A Abhyankar, Veronica Marchante, James L Brighton, Björn Bergmann, “Mathematical Modeling for Continuous Reactive Extrusion of Poly Lactic Acid formation by Ring Opening Polymerization Considering Metal/Organic Catalyst and Alternative Energies” International Journal of Chemical, Nuclear, Materials and Metallurgical Engineering-( Vol:9, No:2, 2015)
5. A. Ojha, N. Vyas, and Satya P Dubey, “Gas phase structural stability of neutral and zwitterionic forms of alanine in presence of (H₂O)_n=1–7 clusters: A density functional theory study,” Comput. Theor. Chem., vol. 1002, pp. 16–23, Dec. 2012.

 

 

Mahendra Nath Roy is the Head and Professor in Department of Chemistry at University of North Bengal, India. His research interests are in the areas of “Hostguest inclusion complexes, ionic liquids, solution thermodynamics and polymer chemistry”. He reviewed 28 PhD thesis and many referred research papers and authored over 200 research articles and books in Chemistry. He has received award of One Time Grant under Basic Scientific Research from University Grants Commission, Prof. Suresh C Ameta Award from Indian Chemical Society and has been recently awarded with CRSI Bronze Medal 2017 by Chemical Research Society of India for his excellence in chemical research throughout his career.

We need vitamin B and vitamin C every day for our growth, but if we take them in surplus/less amounts, our growth will be hampered. If these vitamins are taken into our body in encapsulated form, body takes these vitamins according to its requirements and the growth will be normal. Encapsulation of the vitamins is very important to protect these important biomolecules from external hazards, i.e., oxidation, sensitization, photolytic cleavage etc.; for the regulatory delivery of necessary amount of vitamin at the targeted site for a period of time efficiently and precisely and; to prevent overdose. In this work, encapsulation of β-cyclodextrin with two vitamins namely, nicotinic acid and ascorbic acid in aqueous medium have been explored by reliable spectroscopic, physicochemical and calorimetric methods as stabilizer, carrier and regulatory releaser of the guest molecules. Stereochemical nature of the inclusion complexes has been explained by 2D NMR spectroscopy. Surface tension and conductivity studies further support the inclusion process. Isothermal titration calorimetric studies have been performed to determine the stoichiometry, association constant and thermodynamic parameters with high accuracy. The outcomes reveal that there is a drop in ΔSO, which is overcome by higher negative value of ΔHO,making the overall inclusion process thermodynamically favorable. Hence, this exclusive study describes that the inclusion complexes can be used as controlled delivery systems in the field of modern biomedical sciences.

 

 

 Figure 1. Encapsulation of nicotinic acid and ascorbic acid with β-CD 

 

 

Recent Publications:

 

1. M. N. Roy*, D. Ekka, J Phys. Chem. B, 2012, 116, 11687.
2. M. N. Roy*, A. Bhattacharjee, Phys. Chem. Chem. Phys. 2010, 12, 14534.
3. M. N. Roy*, A. Roy, S. Saha, Carbohydrate Polymers, 2016, 151, 458-466.
4. M. N. Roy*, S. Saha, T. Ray, S. Basak, New. J. Chem., 2016, 40, 651.
5. M. N. Roy*, S. Saha, M. Kundu, S. Barman, Chemical Physics Letters. 2016, 655, 43.
6. M. N. Roy*, S. Saha, S.Barman and D. Ekka. RSC Adv., 2016, 6, 8881.
7. M. N. Roy*, D. Ekka, Amino Acids, 2013, 45, 755.

 

 

 

 

 

 

Ewelina Tomecka received her MSc in Biotechnology from Warsaw University of Technology in 2011. Now, she is a PhD student at Institute of Biotechnology (WUT) and a member of Chemical Sensors Research Group. Her current research interests include “Development of a microfluidic cardiac cell culture model”.

In recent years, there is a growing interest in the use of nanofibers for cell culture. Nano fibrous materials have many advantages such as: high porosity, high surface to volume ratio and they are structurally similar to extracellular matrix (ECM). Furthermore, nanofibers structure influence on cell orientation, which allow mimicking natural organization of cardiac cells. Most researches use electrospinning for nanofibers fabrication. However, low efficiency of this technique doesn’t allow to use it for large-scale production of nanofibers. We propose a rarely used method - solution blow spinning (SBS), which allows scale-up the nanofibers manufacturing process to the commercial level.This work presents the comparison and evaluation of cardiac cell proliferation on poly-(L-lactic acid) (PLLA) and polyurethane (PU) nano-fibrous mats fabricated by SBS. For the experiments, three different cardiac cell lines were used (figure 1).Cell cultures were performed for seven days on non-modified and protein-modified nanofibers surface. Obtained results of cardiac cell culture on investigated surfaces of nanofibers were compared to results of cardiac cell culture on polystyrene (PS) surfaces modified in the same way. The results showed the all types of investigated cells cultured on nanofibers (PLLA and PU) have more elongated shape than cells cultured on PS surface. Moreover, cells were arranged in parallel to each other, according to fibers orientation. In contrast, cells on PS surfaces were oriented randomly.  Furthermore, in most cases, the cells proliferated better on nanofibers (PLLA and PU) than on PS surfaces modified in the same way. The results indicated that polymeric nanofibers (PLLA and PU) are better substrates for cardiac cell culture than PS surface and they enable cultivating these cells with conditions more similar to in vivo environment.

 

 

Figure. 1. Methodology of the experiments [5].

 

Recent Publications:

 

Miroslaw Kwiatkowski is working an assistant professor at the AGH University of Science and Technology, at the Faculty of Energy and Fuels. Main field of his interests is chemical technology, chemistry and physical chemistry, nanotechnology, material science and engineering, mathematical modelling of the adsorption process, description of the porous structure, an analysis of the influence of the production method on the formation of the porous structure of carbonaceous adsorbents, numerical analysis, computer science, energy efficiency, renewable energies, electrical energy markets and problems connected with waste management as well as economics and management. His published work includes more than 40 papers in international journals and 72 conference proceedings. He is a member of the editorial board of internationals journals as well as a member of the Organizing Committee many international conferences, and a regular reviewer in a reputable international scientific journals. Apart from scientific work Miros³aw Kwiatkowski also does some teaching.

The paper presents the results of the research on the application of the LBET method with the fast multivariant identification procedure as a tool for analysing the microporous structure of carbonaceous materials on the basis of high-temperature gaseous carbon dioxide and methane adsorption isotherms. The analysis involved single, double and triple adsorption isotherms, which is a unique approach to microporous structure analysis. On the basis of the results of calculations, it can be observed that LBET method describe well the analysed adsorption systems. Also, the concurrent analysis of two and three adsorption isotherms enhanced the accuracy of the determined parameters, namely the volume of the first adsorption layer and cluster height, testifying to the effectiveness and justifiability of analysing multiple adsorption isotherms.

Mustapha A Tijjani has expertise in “Extraction, phytochemical analysis, isolation of compounds & structural identification and elucidation as well as pharmacological evaluation of compounds or extracts from plants”. He has worked with many indigenous plants in North Eastern Nigeria that have analgesic, anti-inflammatory, anticonvulsant and antipyretic properties.

Vitex doniana sweet, a plant commonly known black plum, in English, prunier noir in French, dinya in Hausa, ucha koro in Igbo, oori-nla in yoruba and ngarmi in Kanuri, is a medium-sized deciduous tree, 8-18 m high, with a heavy rounded crown and a clear bole up to 5 m. V. doniana is from Verbenaceae family and abundantly occurring in savannah regions.It can be found throughout tropical Africa. The ethanolic extract of Vitex doniana stem bark (11.9 g) was subjected to a silica gel accelerated column chromatography and eluents fractions (150 ml aliquots) obtained were collected and monitored with thin layer chromatography (TLC). Fractions with similar Rf values from same solvents system were poled together. Phytochemical test of all the fractions were perform. Complete elution yielded 48 fractions (150 ml/fraction) which were pooled to 24 fractions and finally to eight fractions and coded. Fraction Vd8-a (56 mg) has gave a single spot a white crystal compound coded V1 on checking with TLC and observed under Ultraviolet lamp .The Rf values was calculated to be 0.433 and melting point was found to be 241-243°C uncorrected. The infrared spectrum of compound V1 shows prominent peaks that corresponds to OHstr (3365 cm-1) and C=0 (1652 cm-1). The 1H NMR (400 MHz) spectrum of compound V1 in DMSO-d6 displayed five singlet signals. It further showed a broad singlet at δ 5.58 integrated for 1 H is due to an olefinic H-atom adjacent to the carbonyl carbon atom. Three signals at δ 3.10` (d, J=9.0 Hz, H-22), 3.59 (m, 1H, 2H-a) and 3.72 (m, 1H, 3H-e) each integrating for one proton is due to an oxymethine protons indicating that three oxymethine H-atoms were present in the compound. The 13C-NMR spectrum showed the presence of 27 carbon atoms, suggesting that may be steroid skeleton and DEPT-135 spectra showed the presence of five CH3, eight CH2, and seven CH groups, and seven quaternary C-atoms. The molecular formula was established as C27H44O7 by HRES-MS positive ion mode m/z 481.3179. Based on the spectral analysis, the compound V1 is thus concluded to have ecdysteroids skeleton and conclusively confirms with 2β, 3β 14α, 20R, 22R, 25-hexahydroxy-5 β cholest-7-ene-6- one, commonly known as 20 hydroxyecdysone. This is the first time this compound was isolated from Vitex doniana sweet.

 

Recent Publications:

1. Mustapha A Tijjani, Garba T Mohammed  Yagana T Alkali, Thiza B Adamu¹, Fanna I Abdurahaman (2017). Phytochemical analysis, analgesic and antipyretic properties of ethanolic leaf extract of Vernonia amygdaline Del. Journal of Herbmed Pharmacology
2. Shettima A Y, Tijani MA, Mekaron K., Henry O. Modu B. and Tijani Y. (2016).Effect of methanolic root extract of Guiera senegalensis on some Biochemical and Hematological Parameters in Albino Rats. The Pharmaceutical and chemical Journal. 3(2): 71-78
3. M.A. Tijjani; S.W. Buba , G.M. Tom,  F.I. Abdulrahman, A.I. Mohammed  B.A Gana.(2014).  Preliminary Phytochemical screening and mineral Content of Nigella Sativa Linn. (Black Caraway) Seed. International Journal of Medicinal Chemistry & Analysis. Vol.4./issue 4. 226-2210.
4. Shettima A.Y. Karumi Y, Sodipo OA,  Usman H and  Tijjani MA. (2013).Gas Chromatography–Mass Spectrometry (GC-MS) Analysis of Bioactive Components of Ethyl acetate Root Extract of Guierasenegalensis J.F. Gmel. Journal of Applied Pharmaceutical Science Vol. 3 (03), pp. 146-150.
5. Mustapha A. Tijjani,  Fanna I. Abdulrahman, Irfan Z. Khan  and Umar K. Sandabe (2012).  The Effects of Ethanolic Extracts of Vitex Doniana Stem bark   on Central and Peripheral Nervous System of  on laboratory Animals. Journal of Applied Pharmaceutical Science. Vol. 02(03).Pp 74-79.

Wangila Tsikhungu Phanice is lecturer of chemistry and Head, Physical science department, Chemistry, University of Kabianga,Kenya from 2009 upto present. Currently she is doing her Ph.D in Analytical-Environmental Chemistry from Egerton University, Kenya. Wangila Tsikhungu Phanice has obtained a Masters degree in Chemistry from Egerton University Kenya.Her research interest includes Analytical-Environmental Systems Toxicology, Food and Indigenous Knowledge Heavy and Trace Metals in Environmental Systems with a view of Analytical Chemistry

Heavy metals presence in the environment is of great ecological significance due to their toxicity at certain concentrations, translocation and nonbiodegradability which is responsible for their accumulation in the biosphere. Pb and Cd concentration of soil and reed plant of Busia and Lugari regions of Western Kenya was investigated with an aim of establishing the level of accumulation of the Cd and Pb metals.The level of Cd was generally high in soil samples compared to Pb. The uptake of Pb by reeds within this region is comparable, with TF of 1.4 and 0.205 for Cyperus papyrus and Typha latifolia reeds respectively.